A synthetic genetic array screen for interactions with the RNA helicase DED1 during cell stress in budding yeast

A synthetic genetic array screen for interactions with the RNA helicase DED1 during cell stress in budding yeast

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AbstractDuring cellular stress it is essential for cells to alter their gene Temperature Limiter Thermostat expression to adapt and survive.Gene expression is regulated at multiple levels, but translation regulation is both a method for rapid changes to the proteome and, as one of the most energy-intensive cellular processes, a way to efficiently redirect cellular resources during stress conditions.Despite this ideal positioning, many of the specifics of how translation is regulated, positively or negatively, during various types of cellular stress remain poorly understood.To further assess this regulation, we examined the essential translation factor Ded1, an RNA helicase I.V. Therapy Accessories that has been previously shown to play important roles in the translational response to cellular stress.

In particular, ded1ded1Saccharomyces cerevisiae.